T cells localized to the androgen-deprived prostate are TH 1 and TH 17 biased

TH-17 cells in rheumatoid arthritis

INTRODUCTION The aim of this study was to quantify the number of T-helper (TH)-17 cells present in rheumatoid arthritis (RA) synovial fluid (SF) and to determine the level of interleukin (IL)-17 cytokine in RA, osteoarthritis (OA) and normal synovial tissue, as well as to examine SF macrophages for the presence of IL-23, IL-27 and interferon (IFN)-gamma. METHODS Peripheral blood (PB) mononucl...

The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury

Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-i...

Novel Genetic Regulation of T Helper 1 ( Th 1 ) / Th 2 Cytokine Production and

expression levels of th-2 and th-17 characteristic genes in healthy tissue versus periodontitis.

the t helper 17 (th17) cells have been suggested to have osteoclast activating effects while t helper 2 (th2) cells are considered to have an osteoprotective role in periodontitis. this study was to compare the markers of th17 cells (rorc2 and il-17 genes) with that of th2 cells (il-4 and gata-3 genes) between healthy and periodontitis tissues.the samples were obtained from patients with period...

Th 17 Cells and Nesfatin-1 are associated with Spontaneous Abortion in the CBA/j × DBA/2 Mouse Model.

The pregnancy and abortion process involves a complex mechanism with various immune cells present in the implantation sites and several hormones associated with pregnancy, such as leptin, ghrelin and nesfatin-1. However, the mechanism underlying spontaneous abortion by maternal T helper 17 (Th17) present in the implantation sites and nesfatin-1, which is of anorexigenic hormones, is not fully u...